Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.72 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | IGF1R | P08069 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.59 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31367926 | 1.00 | EGFR (0.72) | EGFRMKNK1MKNK2IGF1RCDK2 | |
| SCHEMBL30393974 | 0.93 | EGFR (0.75) | EGFRMKNK1MKNK2IGF1RCDK2 | |
| SCHEMBL29974663 | 0.93 | EGFR (0.75) | EGFRMKNK1MKNK2IGF1RCDK2 | |
| SCHEMBL14663468 | 0.93 | EGFR (0.75) | EGFRMKNK1MKNK2IGF1RCDK2 | |
| SCHEMBL14719569 | 0.87 | MKNK1 (0.61) | EGFRMKNK1MKNK2KCNH2 | |
| SCHEMBL29525375 | 0.87 | MKNK2 (0.74) | EGFRMKNK1MKNK2KCNH2HDAC1 | |
| SCHEMBL17822329 | 0.87 | MKNK2 (0.74) | EGFRMKNK1MKNK2KCNH2HDAC1 | |
| SCHEMBL19337189 | 0.87 | EGFR (0.72) | EGFRMKNK1MKNK2IGF1RCDK2 | |
| SCHEMBL30956832 | 0.86 | EGFR (0.58) | EGFRMKNK1MKNK2IGF1RKCNH2 | |
| SCHEMBL29232101 | 0.86 | EGFR (0.58) | EGFRMKNK1MKNK2IGF1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946235-B2 | 2-(2,4,5-substituted-anilino) pyrimidine compounds | ASTRAZENECA AB (SE) | 2015-02-03 | — | — | US | disclosed |
| US-20130053409-A1 | 2-(2,4,5-SUBSTITUTED-ANILINO) PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053409-A1 | 2-(2,4,5-SUBSTITUTED-ANILINO) PYRIMIDINE COMPOUNDS | EGFR, ERBB2, ERBB3 | EGFR 1/4885MKNK1 2749/4885MKNK2 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.