Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 14/20 | 0.59 |
| ▸ | PARP3 | Q9Y6F1 | 14/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14718524 | 0.89 | PARP1 (0.53) | PARP1PARP2PARP3 | |
| SCHEMBL14719675 | 0.87 | PARP1 (0.57) | PARP1PARP2PARP3 | |
| SCHEMBL14718761 | 0.85 | PARP1 (0.59) | PARP1PARP2PARP3 | |
| SCHEMBL14719411 | 0.85 | PARP1 (0.64) | PARP1PARP2PARP3 | |
| SCHEMBL14718766 | 0.84 | PARP1 (0.44) | PARP1PARP2PARP3 | |
| SCHEMBL14719455 | 0.83 | PARP1 (0.53) | PARP1PARP2PARP3 | |
| SCHEMBL14718537 | 0.83 | PARP1 (0.55) | PARP1PARP2PARP3 | |
| SCHEMBL14719023 | 0.81 | PARP1 (0.53) | PARP1PARP2PARP3 | |
| SCHEMBL14718611 | 0.80 | PARP1 (0.57) | PARP1PARP2PARP3 | |
| SCHEMBL14719564 | 0.76 | PARP1 (0.59) | PARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL, INC. (US) | 2013-02-28 | — | — | US | claimed |
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL, INC. (US) | 2013-02-28 | — | — | US | disclosed |
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL, INC. (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP3 | PARP1 1/4885PARP2 2/4885PARP3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.