Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 7/20 | 0.65 |
| ▸ | UBA3 | Q8TBC4 | 7/20 | 0.65 |
| ▸ | UBA1 | P22314 | 13/20 | 0.51 |
| ▸ | UBE2E1 | P51965 | 13/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782474 | 1.00 | NAE1 (0.65) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL782980 | 0.86 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL17145363 | 0.86 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL782699 | 0.86 | NAE1 (0.61) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL783123 | 0.79 | NAE1 (1.00) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL2349048 | 0.79 | NAE1 (0.61) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL12392908 | 0.78 | NAE1 (0.53) | NAE1UBA3UBA1 | |
| SCHEMBL782861 | 0.78 | NAE1 (0.53) | NAE1UBA3UBA1 | |
| SCHEMBL12452319 | 0.76 | NAE1 (0.42) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL18540533 | 0.75 | NAE1 (0.56) | NAE1UBA3UBA1UBE2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |