SCHEMBL14719981

SCHEMBL14719981

CN[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)OC(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.61
ABCB1 P08183 1/20 0.60
FOLH1 Q04609 3/20 0.57
KLK7 P49862 2/20 0.57
KLK5 Q9Y337 2/20 0.57
MMP2 P08253 1/20 0.54
MMP9 P14780 1/20 0.54
HTT P42858 1/20 0.53
ITGB3 P05106 1/20 0.52
ITGA2B P08514 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14719982 1.00 MAPT (0.61) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL16269959 0.92 MAPT (0.53) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL12508122 0.91 MAPT (0.61) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL14719934 0.91 MAPT (0.61) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL17309872 0.90 MAPT (0.68) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL1303931 0.90 MAPT (0.68) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL16557300 0.88 MAPT (0.58) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL14719975 0.87 MAPT (0.57) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL14719974 0.87 MAPT (0.57) MAPTABCB1FOLH1KLK7KLK5
SCHEMBL14729274 0.87 ABCB1 (0.61) MAPTABCB1FOLH1KLK7KLK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583887-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-03-24 US disclosed
US-12559521-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-02-24 US disclosed
US-20240425547-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-26 US disclosed
US-20240409580-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-12 US disclosed
US-12139554-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-11-12 US disclosed
US-12122851-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-10-22 US disclosed
US-20210032286-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-02-04 US disclosed
US-20210032286-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-02-04 US disclosed
US-20210024574-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-01-28 US disclosed
US-20210024574-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-01-28 US disclosed
US-20200377549-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2020-12-03 US disclosed
US-20180258134-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2018-09-13 US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 US disclosed
WO-2013028664-A1 PSMA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2013-02-28 WO disclosed
WO-2013028664-A1 PSMA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2013-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240425547-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-20180258134-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-20240409580-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-12559521-B2 PSMA imaging agents KLK3, PSMA1, PSMA6 MAPT 2115/4885ABCB1 1393/4885FOLH1 4/4885
US-12139554-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-20200377549-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-12583887-B2 PSMA imaging agents KLK3, PSMA3, PSMA1 MAPT 1455/4885ABCB1 1046/4885FOLH1 4/4885
US-20210032286-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-10011632-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-12122851-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-20210024574-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885
US-20160304555-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 MAPT 1246/4885ABCB1 2582/4885FOLH1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.