Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720519 | 0.84 | HRH3 (0.34) | HRH3 | |
| SCHEMBL14720799 | 0.83 | HRH3 (0.32) | HRH3 | |
| SCHEMBL14731171 | 0.82 | FLT3 (0.35) | KCNH2 | |
| SCHEMBL14721393 | 0.82 | HRH3 (0.36) | HRH3KMT2A | |
| SCHEMBL14721517 | 0.81 | HRH3 (0.32) | HRH3 | |
| SCHEMBL14720611 | 0.81 | HRH3 (0.32) | HRH3 | |
| SCHEMBL14720610 | 0.81 | HRH3 (0.32) | HRH3 | |
| SCHEMBL14721036 | 0.80 | HRH3 (0.35) | HRH3CCR2KCNH2 | |
| SCHEMBL14720597 | 0.79 | POLB (0.38) | HRH3KCNH2CYP2D6KMT2A | |
| SCHEMBL14721390 | 0.78 | DRD1 (0.33) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |