Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 5/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721390 | 0.97 | DRD1 (0.33) | HRH3DRD1DRD2SRD5A2CYP2D6 | |
| SCHEMBL14720799 | 0.89 | HRH3 (0.32) | HRH3SLC18A3CCR1 | |
| SCHEMBL14720519 | 0.88 | HRH3 (0.34) | HRH3SLC18A3CCR1 | |
| SCHEMBL14721393 | 0.88 | HRH3 (0.36) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14721332 | 0.86 | HRH3 (0.39) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14720774 | 0.85 | HRH3 (0.40) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14720610 | 0.85 | HRH3 (0.32) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14720611 | 0.85 | HRH3 (0.32) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14721517 | 0.85 | HRH3 (0.32) | HRH3SRD5A2SLC18A3CCR1 | |
| SCHEMBL14721355 | 0.82 | HRH3 (0.35) | HRH3SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |