Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14719887 | 1.00 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL14719819 | 1.00 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL23313010 | 1.00 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL22241748 | 1.00 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL21783194 | 0.90 | BCHE (0.52) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL22242702 | 0.83 | TSHR (0.45) | BCHEACHEPDE4DTSHRAGTR2 | |
| SCHEMBL22756306 | 0.82 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL23273737 | 0.82 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL22756305 | 0.82 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 | |
| SCHEMBL29589236 | 0.82 | BCHE (0.49) | BCHEACHEPDE4DTSHRPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |