Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.58 |
| ▸ | PIK3C2B | O00750 | 10/20 | 0.40 |
| ▸ | MTOR | P42345 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721568 | 0.87 | PIK3CB (0.42) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL14728544 | 0.87 | PIK3CB (0.56) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14720230 | 0.76 | PIK3CB (0.80) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14728354 | 0.75 | PIK3CB (0.45) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14721912 | 0.74 | PIK3CB (0.61) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14720451 | 0.74 | PIK3CB (0.69) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14720284 | 0.71 | PIK3CB (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14728248 | 0.69 | PIK3CB (0.57) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14720235 | 0.67 | PIK3CB (1.00) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3C2B | |
| SCHEMBL14723567 | 0.66 | PIK3CB (0.60) | PIK3CDPIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096605-B2 | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096605-B2 | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096605-B2 | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CA, PI4K2B | PIK3CD 7/4885PIK3CB 6/4885PIK3CG 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.