Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303340 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL22123312 | 0.84 | TP53 (0.40) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL9996739 | 0.81 | TP53 (0.47) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL29818185 | 0.81 | TP53 (0.43) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL4707109 | 0.80 | TP53 (0.49) | KMT2AMEN1BRD4FABP4NPC1 | |
| SCHEMBL3330911 | 0.78 | AURKA (0.49) | GRIK1 | |
| SCHEMBL19283285 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL15389531 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL21590173 | 0.75 | CNR1 (0.44) | KDM4EALDH1A1TSHRHSD17B10MAPT | |
| SCHEMBL30002493 | 0.75 | PARP2 (0.46) | MAPTBRD4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748155-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013026931-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-02-28 | — | — | WO | disclosed |