Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | PKLR | P30613 | 1/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723566 | 0.86 | BRD4 (0.77) | BRD4PKMCREBBP | |
| SCHEMBL14721322 | 0.85 | BRD4 (0.79) | BRD4CREBBP | |
| SCHEMBL14723089 | 0.85 | BRD4 (0.79) | BRD4PKMCREBBP | |
| SCHEMBL14722707 | 0.84 | BRD4 (0.77) | BRD4PKMCREBBP | |
| SCHEMBL14722491 | 0.82 | BRD4 (1.00) | BRD4PKMCREBBP | |
| SCHEMBL14723592 | 0.81 | BRD4 (0.79) | BRD4CREBBP | |
| SCHEMBL16760653 | 0.81 | BRD4 (0.77) | BRD4CREBBP | |
| SCHEMBL14723497 | 0.80 | BRD4 (0.80) | BRD4CREBBP | |
| SCHEMBL16760651 | 0.79 | BRD4 (0.82) | BRD4CREBBP | |
| SCHEMBL14721092 | 0.79 | BRD4 (1.00) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027168-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013028495-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR THE TREATMENT OF MULTIPLE MYELOMA | BIOMARIN PHARMACEUTICAL INC. (US) | 2013-02-28 | — | — | WO | disclosed |