Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128115 | 1.00 | NTRK1 (0.41) | NTRK1RBP4F2RNPY5RNR1H2 | |
| SCHEMBL14723522 | 0.92 | NR1H2 (0.42) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL470735 | 0.91 | NTRK1 (0.42) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL610993 | 0.90 | NTRK1 (0.40) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL1724455 | 0.90 | NTRK1 (0.40) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL457724 | 0.90 | NTRK1 (0.41) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL610961 | 0.90 | NTRK1 (0.41) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL458712 | 0.90 | NTRK1 (0.41) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL457722 | 0.90 | NTRK1 (0.41) | NTRK1F2RNPY5RNR1H2RET | |
| SCHEMBL470570 | 0.90 | NTRK1 (0.43) | NTRK1F2RNPY5RNR1H2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |