Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 11/20 | 0.43 |
| ▸ | UBA3 | Q8TBC4 | 11/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723201 | 0.83 | CSF1R (0.39) | NAE1UBA3CSF1RPRMT5BRAF | |
| SCHEMBL805376 | 0.74 | NAE1 (0.53) | NAE1UBA3CSF1RPRMT5BRAF | |
| SCHEMBL782607 | 0.73 | NAE1 (0.63) | NAE1UBA3CSF1RPRMT5SAE1 | |
| SCHEMBL782553 | 0.72 | NAE1 (0.67) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL15007086 | 0.67 | NAE1 (0.43) | NAE1UBA3EGFR | |
| SCHEMBL15007085 | 0.67 | NAE1 (0.43) | NAE1UBA3 | |
| SCHEMBL783028 | 0.64 | GSK3B (0.56) | CSF1RBRAFTNNI3KGSK3BCDK5 | |
| SCHEMBL21192780 | 0.63 | SAE1 (0.61) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL17866003 | 0.63 | NAE1 (0.48) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL16155027 | 0.63 | NAE1 (0.64) | NAE1UBA3SAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |