Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723592 | 0.88 | BRD4 (0.79) | BRD4CREBBP | |
| SCHEMBL14721092 | 0.86 | BRD4 (1.00) | BRD4CREBBP | |
| SCHEMBL14723497 | 0.85 | BRD4 (0.80) | BRD4CREBBP | |
| SCHEMBL14723496 | 0.85 | BRD4 (0.80) | BRD4CREBBP | |
| SCHEMBL14721977 | 0.83 | BRD4 (1.00) | BRD4CREBBP | |
| SCHEMBL16760653 | 0.83 | BRD4 (0.77) | BRD4CREBBP | |
| SCHEMBL16771882 | 0.83 | BRD4 (0.87) | BRD4CREBBP | |
| SCHEMBL16760651 | 0.81 | BRD4 (0.82) | BRD4CREBBP | |
| SCHEMBL18789171 | 0.81 | BRD4 (0.94) | BRD4CREBBP | |
| SCHEMBL14721322 | 0.79 | BRD4 (0.79) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027168-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2013-02-28 | — | — | WO | disclosed |