Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 15/20 | 0.77 |
| ▸ | PAK4 | O96013 | 9/20 | 0.77 |
| ▸ | AURKA | O14965 | 6/20 | 0.77 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.71 |
| ▸ | PAK3 | O75914 | 4/20 | 0.36 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209031 | 0.87 | PAK1 (1.00) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216579 | 0.85 | PAK1 (0.78) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216550 | 0.85 | PAK1 (0.74) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216545 | 0.84 | PAK1 (0.71) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216562 | 0.83 | PAK1 (0.71) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15209131 | 0.83 | PAK1 (1.00) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216515 | 0.83 | PKN1 (1.00) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216556 | 0.83 | PAK1 (0.80) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15216560 | 0.82 | PAK1 (0.79) | PAK1PAK4AURKAPKN1PAK3 | |
| SCHEMBL15208579 | 0.82 | PAK1 (0.79) | PAK1PAK4AURKAPKN1PAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748159-A1 | SERINE/THREONINE PAK1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| US-8637537-B2 | Serine/threonine kinase inhibitors | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637537-B2 | Serine/threonine kinase inhibitors | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2013026914-A1 | SERINE/THREONINE PAK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | PAK1, AKT1, RB1 | PAK1 1/4885PAK4 22/4885AURKA 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.