Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.80 |
| ▸ | REN | P00797 | 1/20 | 0.80 |
| ▸ | CTSD | P07339 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363914 | 1.00 | BACE1 (0.80) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3365839 | 0.91 | BACE1 (0.84) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3363715 | 0.90 | BACE1 (0.81) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL8272278 | 0.90 | BACE1 (0.81) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3363873 | 0.89 | BACE1 (1.00) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL6033240 | 0.89 | BACE1 (1.00) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3363913 | 0.86 | BACE1 (0.91) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL14723919 | 0.86 | BACE1 (0.91) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL8272603 | 0.86 | BACE1 (0.76) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3363657 | 0.86 | BACE1 (0.91) | BACE1RENCTSDKCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436006-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-05-07 | — | — | US | disclosed |
| US-8426429-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8426429-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | disclosed |
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | disclosed |