Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | TEK | Q02763 | 4/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.48 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489319 | 0.84 | LCK (0.77) | LCKKDRTEKBRAFEIF2AK3 | |
| SCHEMBL5501160 | 0.83 | LCK (0.59) | LCKKDRTEKFGFR4BRAF | |
| SCHEMBL5497037 | 0.83 | LCK (0.59) | LCKKDRTEKFGFR4BRAF | |
| SCHEMBL5503706 | 0.80 | LCK (0.47) | LCKKDRTEKBRAFEIF2AK3 | |
| SCHEMBL5503625 | 0.79 | LCK (0.46) | LCKKDRTEKFGFR4BRAF | |
| SCHEMBL5495900 | 0.78 | LCK (0.71) | LCKKDRTEKBRAFMAPK14 | |
| SCHEMBL5489774 | 0.77 | LCK (0.61) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL5498788 | 0.77 | LCK (0.68) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL5496542 | 0.76 | LCK (0.57) | LCKKDRTEKBRAFMAPK14 | |
| SCHEMBL5502527 | 0.76 | LCK (0.56) | LCKKDRTEKFGFR4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |