Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207570 | 0.83 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL8644295 | 0.78 | PIK3CA (0.73) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL6380 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL276645 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL1771905 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL921632 | 0.75 | EGFR (1.00) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL4147243 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL276644 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL2012400 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 | |
| SCHEMBL17410801 | 0.75 | EGFR (0.60) | EGFRPIK3CAPIK3CDFGFR4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |