Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 0.81 |
| ▸ | KDR | P35968 | 18/20 | 0.81 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.81 |
| ▸ | JAK3 | P52333 | 16/20 | 0.68 |
| ▸ | TEK | Q02763 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.64 |
| ▸ | TYK2 | P29597 | 2/20 | 0.64 |
| ▸ | SYK | P43405 | 2/20 | 0.64 |
| ▸ | BTK | Q06187 | 2/20 | 0.64 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416870 | 0.92 | LCK (0.84) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5503485 | 0.90 | LCK (1.00) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5502058 | 0.89 | LCK (0.80) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5494199 | 0.88 | LCK (0.79) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5496467 | 0.87 | LCK (0.77) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5490270 | 0.85 | LCK (0.75) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5488863 | 0.82 | KDR (0.95) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5495482 | 0.82 | LCK (0.71) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL21416759 | 0.82 | LCK (0.69) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL5491887 | 0.81 | LCK (0.76) | LCKKDRMAPK14JAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |