Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.53 |
| ▸ | LCK | P06239 | 9/20 | 0.53 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497209 | 0.90 | MAPK14 (0.61) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5494682 | 0.85 | MAPK14 (0.59) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL21416867 | 0.85 | MAPK14 (0.59) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5495649 | 0.85 | MAPK14 (0.62) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5496622 | 0.81 | MAPK14 (0.52) | MAPK14LCKKDRJAK3KIT | |
| Bicarbonate SCHEMBL14715594 | 0.79 | MAPK14 (0.66) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5498159 | 0.78 | MAPK14 (0.58) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5489130 | 0.78 | MAPK14 (0.58) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5497028 | 0.78 | MAPK14 (0.58) | MAPK14LCKKDRJAK3KIT | |
| SCHEMBL5491560 | 0.77 | MAPK14 (0.64) | MAPK14LCKKDRJAK3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |