Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14611828 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTL3MBTL1ANPEPTSHR | |
| SCHEMBL13070592 | 0.84 | ANPEP (0.54) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL29888629 | 0.84 | ANPEP (0.54) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL5761505 | 0.84 | ANPEP (0.54) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL1627443 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL13088679 | 0.83 | ANPEP (0.60) | SMN1; SMN2MAPTANPEPTSHRATM | |
| Hydrochloric Acid SCHEMBL5761503 | 0.83 | ANPEP (0.53) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL23102214 | 0.82 | MAPT (0.55) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL12548382 | 0.82 | MAPT (0.55) | SMN1; SMN2MAPTL3MBTL1ANPEPATM | |
| SCHEMBL1161723 | 0.82 | MAPT (0.55) | SMN1; SMN2MAPTL3MBTL1ANPEPATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765789-B1 | N-(1-(1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2013-02-27 | — | — | EP | disclosed |