Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 18/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286516 | 1.00 | KCNJ1 (0.46) | KCNJ1PDE4DKCNH2 | |
| SCHEMBL29195553 | 0.90 | KCNJ1 (0.41) | KCNJ1PDE4DKCNH2 | |
| SCHEMBL2891319 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL286208 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL30444525 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL30444657 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL2899747 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL14726115 | 0.79 | KCNJ1 (0.53) | KCNJ1 | |
| SCHEMBL286489 | 0.78 | KCNJ1 (0.40) | KCNJ1 | |
| SCHEMBL287079 | 0.78 | KCNJ1 (0.47) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744499-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2013028474-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-02-28 | — | — | WO | disclosed |