Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 8/20 | 0.58 |
| ▸ | CTSB | P07858 | 3/20 | 0.57 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994620 | 1.00 | CAPN1 (0.58) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL14673120 | 0.93 | CAPN1 (0.65) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL16488740 | 0.93 | CAPN1 (0.65) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL18626009 | 0.93 | CAPN1 (0.65) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL14673121 | 0.93 | CAPN1 (0.65) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL19501058 | 0.89 | CAPN1 (0.54) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL7202436 | 0.89 | CAPN1 (0.59) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL7202432 | 0.89 | CAPN1 (0.59) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL27559117 | 0.89 | CAPN1 (0.59) | CAPN1CTSBXIAPOPRM1SLC6A2 | |
| SCHEMBL24171144 | 0.87 | CAPN1 (0.51) | CAPN1CTSBXIAPOPRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593145-B2 | Secondary structure stabilized NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-20160368947-A1 | NMDA Receptor Modulators and Uses Thereof | INNOVIVA TRC HOLDINGS LLC | 2016-12-22 | — | — | US | disclosed |
| US-20160115197-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | INNOVIVA TRC HOLDINGS LLC | 2016-04-28 | — | — | US | disclosed |
| US-9101612-B2 | Secondary structure stabilized NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20130053325-A1 | Secondary Structure Stabilized NMDA Receptor Modulators and Uses Thereof | INNOVIVA TRC HOLDINGS LLC | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053325-A1 | Secondary Structure Stabilized NMDA Receptor Modulators and Uses Thereof | GRIN2A, GRIN1, GRIN3A | CAPN1 1536/4885CTSB 4297/4885XIAP 2571/4885 |
| US-20160368947-A1 | NMDA Receptor Modulators and Uses Thereof | GRIN1, GRIN2A, GRIN3A | CAPN1 866/4885CTSB 4049/4885XIAP 2796/4885 |
| US-20160115197-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN2A, GRIN1, GRIN3A | CAPN1 1536/4885CTSB 4297/4885XIAP 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.