Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.81 |
| ▸ | JAK2 | O60674 | 11/20 | 0.77 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14729726 | 0.93 | SYK (0.81) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717130 | 0.92 | SYK (0.82) | SYKJAK2 | |
| SCHEMBL14716901 | 0.92 | SYK (0.82) | SYKJAK2 | |
| SCHEMBL14729727 | 0.92 | SYK (0.81) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30604962 | 0.89 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717136 | 0.89 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717118 | 0.89 | SYK (0.88) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716910 | 0.89 | SYK (0.76) | SYKJAK2 | |
| SCHEMBL14716783 | 0.88 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717162 | 0.88 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053346-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | ENDO PHARMACEUTICALS INC (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2013028818-A1 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | ENDO PHARMACEUTICALS INC. (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053346-A1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF | THPO, TYMP, TYMS | SYK 741/4885JAK2 139/4885JAK1 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.