SCHEMBL14729762

SCHEMBL14729762

O=C(O)[C@@H]1CC12CCN(c1ccc(Nc3nc(N4CCCCCC4)nc4cn[nH]c(=O)c34)cn1)CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 18/20 1.00
JAK2 O60674 12/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29635081 1.00 SYK (1.00) SYKJAK2
SCHEMBL14717049 1.00 SYK (1.00) SYKJAK2
SCHEMBL14729787 0.90 SYK (0.83) SYKJAK2
SCHEMBL17896467 0.90 SYK (1.00) SYKJAK2
SCHEMBL29635199 0.90 SYK (1.00) SYKJAK2
SCHEMBL14717740 0.90 SYK (1.00) SYKJAK2
SCHEMBL29635087 0.90 SYK (1.00) SYKJAK2
SCHEMBL14716749 0.90 SYK (1.00) SYKJAK2
SCHEMBL14717244 0.88 SYK (1.00) SYKJAK2
SCHEMBL22102151 0.88 SYK (0.82) SYKJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013028818-A1 PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF ENDO PHARMACEUTICALS INC. (US) 2013-02-28 WO disclosed