Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 12/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.68 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.68 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730928 | 0.85 | RIPK2 (0.70) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2595186 | 0.84 | RIPK2 (0.73) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2589394 | 0.84 | RIPK2 (0.73) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2595620 | 0.84 | RIPK2 (1.00) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2592512 | 0.82 | RIPK2 (0.84) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL31248455 | 0.81 | RIPK2 (1.00) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2595069 | 0.81 | RIPK2 (1.00) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2595766 | 0.81 | RIPK2 (1.00) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL17059481 | 0.80 | RIPK2 (0.58) | RIPK2KCNH2TGFBR1GAKMAPK14 | |
| SCHEMBL2592842 | 0.80 | RIPK2 (0.74) | RIPK2KCNH2TGFBR1GAKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160060222-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2016-03-03 | — | — | US | disclosed |
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060222-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K2, MAP4K2 | RIPK2 326/4885KCNH2 1159/4885TGFBR1 3359/4885 |
| US-20130053375-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K2, MAP4K2 | RIPK2 326/4885KCNH2 1159/4885TGFBR1 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.