Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13062621 | 1.00 | TYK2 (0.46) | TYK2NPC1RAB9APAK1PDE4D | |
| SCHEMBL3782258 | 0.94 | TYK2 (0.49) | TYK2NPC1RAB9APDE4D | |
| SCHEMBL3782259 | 0.94 | TYK2 (0.49) | TYK2NPC1RAB9APDE4D | |
| SCHEMBL3781682 | 0.92 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL3781686 | 0.92 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL3780581 | 0.91 | TYK2 (0.52) | TYK2PDE4D | |
| SCHEMBL3780584 | 0.91 | TYK2 (0.52) | TYK2PDE4D | |
| SCHEMBL3776209 | 0.91 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL3776204 | 0.91 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL3779987 | 0.91 | TYK2 (0.53) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389527-B2 | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-05 | — | — | US | claimed |
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | disclosed |