Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13062262 | 1.00 | TYK2 (0.49) | TYK2PDE4DTTKSTAT3ERN1 | |
| SCHEMBL14732068 | 0.94 | TYK2 (0.47) | TYK2PDE4DTTK | |
| SCHEMBL13062535 | 0.94 | TYK2 (0.47) | TYK2PDE4DTTK | |
| SCHEMBL14732140 | 0.92 | TYK2 (0.51) | TYK2PDE4DTTKSTAT3 | |
| SCHEMBL13062287 | 0.92 | TYK2 (0.51) | TYK2PDE4DTTKSTAT3 | |
| SCHEMBL3778247 | 0.91 | TYK2 (0.47) | TYK2PDE4DTTKSTAT3ERN1 | |
| SCHEMBL3774320 | 0.91 | TYK2 (0.47) | TYK2PDE4DTTKSTAT3ERN1 | |
| SCHEMBL3774322 | 0.91 | TYK2 (0.47) | TYK2PDE4DTTKSTAT3ERN1 | |
| SCHEMBL3778250 | 0.91 | TYK2 (0.47) | TYK2PDE4DTTKSTAT3ERN1 | |
| SCHEMBL3821439 | 0.91 | TYK2 (0.47) | TYK2PDE4DTTKSTAT3ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | claimed |
| US-8389527-B2 | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-05 | — | — | US | claimed |