Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.56 |
| ▸ | BACE2 | Q9Y5Z0 | 19/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1977346 | 0.93 | BACE1 (0.56) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1977348 | 0.93 | BACE1 (0.56) | BACE1BACE2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL13268453 | 0.91 | BACE1 (0.55) | BACE1BACE2PSEN1PSEN2APH1B | |
| Formic Acid SCHEMBL14732151 | 0.86 | BACE1 (0.55) | BACE1BACE2PSEN1PSEN2APH1B | |
| Formic Acid SCHEMBL14759734 | 0.84 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL15676848 | 0.83 | BACE1 (0.52) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL12980225 | 0.82 | BACE1 (0.59) | BACE1BACE2 | |
| SCHEMBL14732152 | 0.81 | BACE1 (0.62) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL16900333 | 0.81 | BACE1 (0.45) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL13268447 | 0.81 | BACE1 (0.58) | BACE1BACE2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389513-B2 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |