Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 14/20 | 0.61 |
| ▸ | GSK3A | P49840 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733516 | 0.81 | DYRK1A (0.68) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733594 | 0.81 | DYRK1A (0.70) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733427 | 0.81 | DYRK1A (0.70) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733519 | 0.80 | DYRK1A (0.65) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL16037543 | 0.80 | DYRK1A (0.65) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733549 | 0.79 | DYRK1A (0.74) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733592 | 0.79 | DYRK1A (0.77) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL14733467 | 0.78 | DYRK1A (0.69) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL16040009 | 0.77 | DYRK1A (0.64) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 | |
| SCHEMBL31061183 | 0.77 | DYRK1A (1.00) | DYRK1ADYRK1BGSK3AGSK3BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026806-A1 | DYRK1 INHIBITORS AND USES THEREOF | EXONHIT SA (FR) | 2013-02-28 | — | — | WO | disclosed |