Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | MPC2 | O95563 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733601 | 1.00 | PPARG (0.51) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL14213590 | 0.91 | PPARG (0.55) | PPARGCYP3A4MPC2CYP2C8CYP2C9 | |
| SCHEMBL14213574 | 0.91 | PPARG (0.55) | PPARGCYP3A4MPC2CYP2C8CYP2C9 | |
| SCHEMBL14213616 | 0.91 | PPARG (0.55) | PPARGCYP3A4MPC2CYP2C8CYP2C9 | |
| SCHEMBL14213595 | 0.89 | PPARG (0.45) | PPARGCYP3A4FFAR1ALDH1A1TP53 | |
| SCHEMBL14213641 | 0.89 | PPARG (0.45) | PPARGCYP3A4CYP26A1CYP26B1FFAR1 | |
| SCHEMBL14213582 | 0.89 | PPARG (0.45) | PPARGCYP3A4FFAR1ALDH1A1TP53 | |
| SCHEMBL14213583 | 0.89 | PPARG (0.45) | PPARGCYP3A4CYP26A1CYP26B1FFAR1 | |
| SCHEMBL14213628 | 0.89 | PPARG (0.45) | PPARGCYP3A4FFAR1ALDH1A1TP53 | |
| SCHEMBL14213596 | 0.89 | PPARG (0.45) | PPARGCYP3A4CYP26A1CYP26B1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053350-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053350-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PPARD, PPARG, PPARA | PPARG 2/4885CYP3A4 2029/4885RXRA 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.