Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PRF1 | P14222 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737363 | 0.92 | PDE4D (0.52) | PDE4DKDM4ELMNAPDE4APDE4B | |
| SCHEMBL2591590 | 0.88 | PDE4D (0.56) | PDE4DKDM4ELMNAPDE4APDE4B | |
| SCHEMBL14750841 | 0.88 | PDE4D (0.55) | PDE4DPRF1PDE4APDE4BPDE4C | |
| SCHEMBL2591415 | 0.87 | PDE4D (0.58) | PDE4DKDM4ELMNAPDE4APDE4B | |
| SCHEMBL14736841 | 0.87 | PDE4D (0.58) | PDE4DKDM4ELMNAPDE4APDE4B | |
| SCHEMBL2590947 | 0.86 | PDE4D (0.56) | PDE4DPRF1PDE4APDE4BPDE4C | |
| SCHEMBL2592433 | 0.86 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2594814 | 0.85 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2584267 | 0.85 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2585094 | 0.85 | PDE4D (0.57) | PDE4DPRF1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |