Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737718 | 0.90 | KDM4E (0.41) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL2588133 | 0.87 | PDE4D (0.42) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL2591942 | 0.87 | PDE4D (0.43) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL2593102 | 0.86 | PDE4D (0.46) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL14737337 | 0.86 | PDE4D (0.46) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL14736730 | 0.85 | PDE4D (0.44) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL2584132 | 0.84 | PDE4D (0.44) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL2583558 | 0.83 | PDE4D (0.38) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL14737512 | 0.83 | PDE4D (0.45) | KDM4ELMNAPDE4DHDAC4HDAC2 | |
| SCHEMBL14737436 | 0.83 | PDE4D (0.46) | KDM4ELMNAPDE4DHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |