Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593047 | 0.91 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL2591497 | 0.88 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14737087 | 0.88 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL2592244 | 0.87 | PDE4D (0.40) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14737202 | 0.87 | PDE4D (0.43) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14737352 | 0.86 | PDE4D (0.38) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14738673 | 0.86 | PDE4D (0.43) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14736739 | 0.86 | PDE4D (0.43) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL2587604 | 0.86 | PDE4D (0.38) | PDE4DHDAC4HDAC2HDAC8MAOB | |
| SCHEMBL14737217 | 0.86 | PDE4D (0.43) | PDE4DHDAC4HDAC2HDAC8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |