Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | PLK4 | O00444 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | BLK | P51451 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589375 | 0.91 | KDR (0.40) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2591824 | 0.87 | KDR (0.37) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2585899 | 0.87 | KDR (0.36) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2591389 | 0.86 | KDR (0.38) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2589602 | 0.86 | TP53 (0.39) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2591018 | 0.85 | KDR (0.35) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2586039 | 0.85 | KDR (0.35) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2584442 | 0.84 | PDE4D (0.35) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL2591966 | 0.84 | CYP1A2 (0.37) | KDRROCK1ROCK2RPS6KB1TAOK1 | |
| SCHEMBL14737175 | 0.84 | KDR (0.34) | KDRROCK1ROCK2RPS6KB1TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |