Sugi Predict

Sugi Predict / Compounds / SCHEMBL14734824

SCHEMBL14734824

SCHEMBL14734824

COc1ccc(-c2ccc3c(c2)CNC3=O)c(OCC(C)(C)OC(=O)CC(C)C)c1OC

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLQ O75417 1/20 0.36
▸ PRF1 P14222 1/20 0.35
▸ MAPKAPK2 P49137 1/20 0.35
▸ GSK3B P49841 2/20 0.34
▸ DAPK3 O43293 1/20 0.34
▸ NTRK1 P04629 1/20 0.34
▸ PIM1 P11309 1/20 0.34
▸ FLT3 P36888 1/20 0.34
▸ ROCK1 Q13464 1/20 0.34
▸ CLK4 Q9HAZ1 1/20 0.34
▸ PRKCI P41743 1/20 0.34
▸ TARS1 P26639 1/20 0.34
▸ TDP2 O95551 2/20 0.33
▸ AKT1 P31749 1/20 0.33
▸ CHEK1 O14757 1/20 0.33
▸ CYP2C19 P33261 1/20 0.32
▸ BRAF P15056 1/20 0.32
▸ GPR119 Q8TDV5 1/20 0.32
▸ ADORA1 P30542 1/20 0.31
▸ LIPG Q9Y5X9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14734754 0.90 GSK3B (0.38) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2584838 0.89 POLQ (0.37) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL14738236 0.89 POLQ (0.37) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2584358 0.89 POLQ (0.39) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL14734800 0.89 PRKCI (0.36) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL14734803 0.88 GSK3B (0.36) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2592055 0.87 POLQ (0.35) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2593340 0.87 POLQ (0.35) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2584978 0.86 POLQ (0.35) POLQPRF1MAPKAPK2GSK3BDAPK3
SCHEMBL2591973 0.86 POLQ (0.35) POLQPRF1MAPKAPK2GSK3BDAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2563770-B1 BIARYL PHOSPHODIESTERASE INHIBITORS LEO PHARMA AS (DK) 2016-03-23 — — EP disclosed
US-9051290-B2 Biaryl phosphodiesterase inhibitors LEO PHARMA A/S (DK) 2015-06-09 — — US disclosed
US-9051290-B2 Biaryl phosphodiesterase inhibitors LEO PHARMA A/S (DK) 2015-06-09 — — US disclosed
US-9051290-B2 Biaryl phosphodiesterase inhibitors LEO PHARMA A/S (DK) 2015-06-09 — — US disclosed
US-20130059853-A1 BIARYL PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2013-03-07 — — US disclosed
US-20130059853-A1 BIARYL PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2013-03-07 — — US disclosed
US-20130059853-A1 BIARYL PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2013-03-07 — — US disclosed
EP-2563770-A1 BIARYL PHOSPHODIESTERASE INHIBITORS Leo Pharma A/S (DK) 2013-03-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130059853-A1 BIARYL PHOSPHODIESTERASE INHIBITORS PDE3B, PDE3A, PDE4A POLQ 1717/4885PRF1 3550/4885MAPKAPK2 2431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.