Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.61 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14734877 | 1.00 | PLK1 (0.61) | PLK1BRD4BRDTTTKRAD52 | |
| SCHEMBL1675599 | 0.88 | PLK1 (0.67) | PLK1BRD4BRDTTTK | |
| SCHEMBL1675595 | 0.88 | PLK1 (0.67) | PLK1BRD4BRDTTTK | |
| SCHEMBL1675891 | 0.84 | PLK1 (0.67) | PLK1BRD4BRDTTTK | |
| SCHEMBL1675890 | 0.84 | PLK1 (0.67) | PLK1BRD4BRDTTTK | |
| SCHEMBL12301383 | 0.83 | PLK1 (0.82) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL1675782 | 0.83 | PLK1 (0.82) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL12301382 | 0.83 | PLK1 (0.82) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL31405290 | 0.83 | PLK1 (0.82) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL1675901 | 0.82 | PLK1 (0.81) | PLK1BRD4BRDTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205241-B1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2014-05-21 | — | — | EP | disclosed |
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |