Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.58 |
| ▸ | BRD4 | O60885 | 12/20 | 0.56 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.56 |
| ▸ | PDXK | O00764 | 1/20 | 0.51 |
| ▸ | WEE1 | P30291 | 1/20 | 0.51 |
| ▸ | NEK3 | P51956 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675652 | 0.93 | PLK1 (0.57) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1675878 | 0.92 | PLK1 (0.65) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675893 | 0.91 | PLK1 (0.60) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675739 | 0.91 | PLK1 (0.60) | PLK1BRD4BRDTPTK2PLK3 | |
| SCHEMBL1675594 | 0.90 | PLK1 (0.65) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675643 | 0.90 | PLK1 (0.57) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675766 | 0.89 | PLK1 (0.57) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675851 | 0.89 | PLK1 (0.57) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675694 | 0.88 | PLK1 (0.55) | PLK1BRD4BRDTDCLK1LRRK2 | |
| SCHEMBL1675665 | 0.87 | PLK1 (0.54) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-B1 | Polo-like kinase inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2014-08-13 | — | — | EP | claimed |
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | claimed |