Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 8/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675895 | 0.92 | PLK1 (0.43) | PLK1BRD4BRDT | |
| SCHEMBL1675925 | 0.91 | PTPN11 (0.30) | — | |
| SCHEMBL30135708 | 0.80 | PLK1 (0.53) | PLK1BRD4BRDT | |
| SCHEMBL1559681 | 0.80 | PLK1 (0.53) | PLK1BRD4BRDT | |
| SCHEMBL1560746 | 0.80 | PLK1 (0.51) | PLK1BRD4BRDT | |
| SCHEMBL1559399 | 0.79 | PLK1 (0.52) | PLK1BRD4BRDT | |
| SCHEMBL1559101 | 0.77 | PLK1 (0.33) | PLK1BRD4BRDT | |
| SCHEMBL1560603 | 0.77 | KDM4E (0.32) | PLK1 | |
| SCHEMBL1675579 | 0.76 | KMT2A (0.33) | PLK1 | |
| SCHEMBL4076292 | 0.72 | PIK3CA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |