Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735567 | 0.90 | PTK2 (0.57) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL14735595 | 0.89 | PTK2 (0.56) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3535040 | 0.87 | PTK2 (0.60) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL14735591 | 0.87 | MAPK14 (0.62) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL14735558 | 0.85 | MAPK14 (0.55) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3586321 | 0.81 | PTK2 (0.68) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3530115 | 0.80 | PTK2 (0.84) | PTK2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL2951313 | 0.80 | MAPK14 (0.84) | PTK2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21449688 | 0.78 | MAPK14 (0.70) | PTK2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13499154 | 0.78 | MAPK14 (0.70) | PTK2PTK2BMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | claimed |
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | disclosed |