SCHEMBL14735491

SCHEMBL14735491

COC=C(C(=O)O)c1ccccc1COc1cc(C=NOCc2ccccc2)ccc1OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.55
ALDH1A1 P00352 4/20 0.49
LMNA P02545 6/20 0.47
NPC1 O15118 2/20 0.47
MAPT P10636 3/20 0.47
KDM4E B2RXH2 2/20 0.47
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
AMY1A P0DUB6 1/20 0.46
HPGD P15428 1/20 0.45
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GALR3 O60755 1/20 0.43
NR2F2 P24468 1/20 0.43
APP P05067 2/20 0.43
NFKB1 P19838 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14735489 1.00 HIF1A (0.55) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL14735487 1.00 HIF1A (0.55) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895007 0.93 HIF1A (0.61) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895004 0.93 HIF1A (0.61) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895005 0.93 HIF1A (0.61) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL14735490 0.93 HIF1A (0.57) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895006 0.87 HIF1A (0.62) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895173 0.87 HIF1A (0.58) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895171 0.87 HIF1A (0.58) HIF1AALDH1A1LMNANPC1MAPT
SCHEMBL9895172 0.87 HIF1A (0.58) HIF1AALDH1A1LMNANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2565180-A2 ALPHA-ARYLMETHOXYACRYLATE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME Oscotec Inc. (KR) 2013-03-06 EP disclosed