Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.69 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.61 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | ABL2 | P42684 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499154 | 0.94 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3528828 | 0.92 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3533020 | 0.92 | PTK2 (0.60) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3538354 | 0.91 | PTK2 (0.59) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3535040 | 0.90 | PTK2 (0.60) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3534723 | 0.90 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL29623272 | 0.82 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL19350921 | 0.82 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3534301 | 0.81 | PTK2 (0.89) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL28942120 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912998-B1 | PYRAZOLE DERIVATIVES HAVING TYROSINKINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | claimed |