Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.66 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.63 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.63 |
| ▸ | CLK2 | P49760 | 1/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305003 | 0.83 | CDC7 (0.52) | CDC7PIM1MAPK13DAPK3ROCK2 | |
| SCHEMBL3343878 | 0.82 | CDC7 (0.44) | CDC7PIM1MAPK13DAPK3ROCK2 | |
| SCHEMBL4245829 | 0.80 | CDC7 (1.00) | CDC7PIM1MAPK13DAPK3ROCK2 | |
| SCHEMBL383588 | 0.80 | PIM1 (0.70) | CDC7PIM1GSK3BCSNK2A1PDE5A | |
| SCHEMBL383394 | 0.80 | PIM1 (0.53) | CDC7PIM1GSK3BCSNK2A1PDE5A | |
| SCHEMBL385584 | 0.78 | CDC7 (1.00) | CDC7PIM1MAPK13DAPK3ROCK2 | |
| SCHEMBL385628 | 0.77 | PIM1 (0.49) | CDC7PIM1MAPK1GSK3BCSNK2A1 | |
| SCHEMBL4245493 | 0.76 | CDC7 (1.00) | CDC7PIM1MAPK13DAPK3ROCK2 | |
| SCHEMBL385518 | 0.76 | PIM1 (0.67) | CDC7PIM1GSK3BCSNK2A1PDE5A | |
| SCHEMBL3339927 | 0.76 | PIM1 (0.46) | CDC7PIM1MAPK13DAPK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074114-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2013-03-06 | — | — | EP | claimed |
| EP-2074114-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2013-03-06 | — | — | EP | disclosed |