Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100452 | 0.94 | GRM5 (0.57) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL102127 | 0.89 | GRM5 (0.72) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30485551 | 0.89 | GRM5 (0.72) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL104046 | 0.81 | GRM5 (0.57) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30795180 | 0.81 | GRM5 (0.57) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL104166 | 0.75 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL104353 | 0.75 | GRM5 (0.58) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| Dipraglurant SCHEMBL30079764 | 0.75 | GRM5 (1.00) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Dipraglurant SCHEMBL103033 | 0.75 | GRM5 (1.00) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL102385 | 0.74 | GRM5 (0.47) | GRM5NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765795-B1 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2013-03-06 | — | — | EP | claimed |