Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.60 |
| ▸ | SMO | Q99835 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620345 | 0.85 | PIK3CA (0.74) | PIK3CACYP3A4PIK3CGDYRK1AFSCN1 | |
| SCHEMBL1621507 | 0.82 | SMO (0.68) | PIK3CACYP3A4PIK3CGSMO | |
| SCHEMBL3142719 | 0.81 | PIK3CA (1.00) | PIK3CACYP3A4PIK3CGDYRK1A | |
| SCHEMBL1621000 | 0.81 | PIK3CG (0.69) | PIK3CACYP3A4PIK3CGSMO | |
| SCHEMBL1621665 | 0.81 | PIK3CA (0.73) | PIK3CACYP3A4PIK3CGSMO | |
| SCHEMBL3131485 | 0.80 | PIK3CA (1.00) | PIK3CACYP3A4PIK3CGDYRK1A | |
| SCHEMBL3146741 | 0.80 | PIK3CA (0.74) | PIK3CACYP3A4PIK3CGDYRK1A | |
| SCHEMBL1621634 | 0.80 | PIK3CG (0.67) | PIK3CACYP3A4PIK3CGDYRK1AFSCN1 | |
| SCHEMBL1620363 | 0.79 | SMO (0.65) | PIK3CACYP3A4PIK3CGSMO | |
| SCHEMBL1621112 | 0.79 | PIK3CG (0.79) | PIK3CACYP3A4PIK3CGSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | claimed |