Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.37 |
| ▸ | PDE4A | P27815 | 6/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.35 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.32 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14734706 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL14735867 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL14737726 | 0.97 | KDM4E (0.40) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL2592005 | 0.97 | KDM4E (0.40) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL14738111 | 0.95 | KDM4E (0.40) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL2588945 | 0.92 | KDM4E (0.41) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL2584453 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL14738034 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE4DTP53 | |
| SCHEMBL14737092 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE4DPDE4A | |
| SCHEMBL2581888 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1HPGDPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |