Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736465 | 0.87 | PDE10A (0.47) | HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL11297901 | 0.83 | HDAC1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL14736136 | 0.83 | HDAC1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL6364987 | 0.80 | KMT2A (0.52) | HDAC1HDAC6SMN1; SMN2NOTUM | |
| SCHEMBL14118418 | 0.80 | HDAC1 (0.48) | HDAC1HDAC6 | |
| SCHEMBL14736627 | 0.80 | HDAC1 (0.48) | HDAC1HDAC6 | |
| SCHEMBL14736860 | 0.80 | HDAC1 (0.54) | HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL14736132 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6 | |
| SCHEMBL2035500 | 0.77 | NR1H3 (0.58) | SMN1; SMN2NOTUM | |
| SCHEMBL21471362 | 0.77 | KDM4A (0.47) | HDAC1HDAC6SMN1; SMN2KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | HDAC1 125/4885HDAC6 182/4885SMN1; SMN2 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.