Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737211 | 0.91 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14736917 | 0.88 | PDE4D (0.38) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14738068 | 0.87 | PDE4D (0.38) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14737420 | 0.86 | PDE4D (0.38) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14737897 | 0.86 | PDE4D (0.37) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14736991 | 0.86 | PDE4D (0.37) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14737378 | 0.85 | PDE4D (0.40) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14736895 | 0.84 | PDE4D (0.36) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14736811 | 0.84 | PDE4D (0.36) | PDE4DHDAC4HDAC2HDAC8KDM4E | |
| SCHEMBL14737333 | 0.84 | PDE4D (0.39) | PDE4DHDAC4HDAC2HDAC8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE4A | PDE4D 10/4885HDAC4 105/4885HDAC2 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.