Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19128166 | 0.90 | CHRM1 (0.80) | CHRM1KCNH2 | |
| SCHEMBL16948140 | 0.90 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL18204273 | 0.90 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL18204246 | 0.90 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL19145943 | 0.88 | CHRM1 (0.78) | CHRM1KCNH2 | |
| SCHEMBL18204247 | 0.88 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL16948125 | 0.88 | CHRM1 (1.00) | CHRM1 | |
| SCHEMBL19370079 | 0.88 | CHRM1 (0.77) | CHRM1KCNH2 | |
| SCHEMBL12065187 | 0.88 | CHRM1 (0.77) | CHRM1KCNH2 | |
| SCHEMBL19370075 | 0.88 | CHRM1 (0.77) | CHRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883850-B2 | Naphthalene carboxamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883850-B2 | Naphthalene carboxamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883850-B2 | Naphthalene carboxamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130059860-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2013-03-07 | — | — | US | disclosed |
| US-20130059860-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2013-03-07 | — | — | US | disclosed |
| US-20130059860-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059860-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, CNR1, OPRL1 | CHRM1 1/4885KCNH2 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.