Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192122 | 0.91 | FOLH1 (0.38) | BACE1NMT2NMT1FOLH1 | |
| SCHEMBL2470628 | 0.86 | BACE1 (0.41) | BACE1NMT2NMT1FOLH1BACE2 | |
| SCHEMBL676216 | 0.84 | GRIN2D (0.43) | BACE1NMT2NMT1 | |
| SCHEMBL28865257 | 0.84 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL28865256 | 0.84 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL1351713 | 0.82 | DPP4 (0.39) | BACE1BACE2 | |
| SCHEMBL1717071 | 0.81 | BACE1 (0.47) | BACE1NMT2NMT1BACE2 | |
| SCHEMBL28018179 | 0.81 | BACE1 (0.47) | BACE1NMT2NMT1BACE2 | |
| SCHEMBL1649812 | 0.81 | FOLH1 (0.48) | NMT2NMT1FOLH1 | |
| SCHEMBL3122465 | 0.81 | GRIN2D (0.42) | BACE1NMT2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297868-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | Hoth Therapeutics, Inc. (US) | 2024-01-03 | — | — | EP | claimed |
| WO-2022182658-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. (US) | 2022-09-01 | — | — | WO | claimed |
| EP-2958915-A1 | AZABENZIMIDAZOLE COMPOUNDS AS INHIBITORS OF PDE4 ISOZYMES FOR THE TREATMENT OF CNS AND OTHER DISORDERS | Pfizer Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014128585-A1 | AZABENZIMIDAZOLE COMPOUNDS AS INHIBITORS OF PDE4 ISOZYMES FOR THE TREATMENT OF CNS AND OTHER DISORDERS | PFIZER INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| EP-2751116-A1 | HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS | Pfizer Inc (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013030713-A1 | HEXAHYDROPYRANO [3,4-D][1,3] THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2013-03-07 | — | — | WO | disclosed |