Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747035 | 0.89 | SYK (0.46) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738200 | 0.89 | SYK (0.46) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738713 | 0.88 | CNR1 (0.41) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738711 | 0.88 | CNR1 (0.41) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738188 | 0.85 | SYK (0.48) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738528 | 0.85 | SYK (0.47) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14751219 | 0.85 | SYK (0.48) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738230 | 0.84 | SYK (0.43) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14737612 | 0.84 | SYK (0.60) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746992 | 0.83 | JAK2 (0.43) | SYKJAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |